As usual I'll be making a NES game (or at least I'll try to); this time I'll be using:

• C++ (and maybe a pinch of Assembly) with the LLVM-MOS SDK
• NEXXT for the 2bpp graphics
• LDtk for level design (if the game happens to have levels)
• If I ever get to it, I may try using FamiTracker and/or FamiStudio for sound/music (otherwise I may just use public domain stuff)

(the game on the screenshot is one I'm working with an artist/designer and a musician, a remake of my LD53 entry for this year's NESdev Compo)