Sadistic science professor R. E. Searcher, Ph. D., has met with an unfortunate incident that not even tenure can alleviate. In between kidnapping and "instructing" this year's batch of ill-fated freshman, Professor Searcher has somehow managed to turn his most recent instrument of torture- his shrink ray- against himself.

Having shrunk to the size of a lima bean and fallen through the drain in his classroom's much-used emergency eye wash station, Professor Searcher must now navigate the sewer tunnels and collect beakers of chemical energy before the effects of the shrink ray wear off and he becomes crushed to death in the tiny world within the sewer pipes.

Welcome to Science 101: The Sewer Chronicles, where exams are cumulative and there is no extra credit.